Epothilone B (EPO906)

Catalog No. A10360

Epothilone B (EPO906)是一种紫杉醇样microtubule稳定剂。

Product Citations

Yicheng Zhu, .et al. Combinatrial treatment of anti-High Mobility Group Box-1 monoclonal antibody and epothilone B improves functional recovery after spinal cord contusion injury, Neurosci Res, 2021, Apr 17 PMID: 33864880

Technical details

Catalog Num	A10360
M. Wt	507.7
Formula	C27H41NO6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	152044-54-7
Synonyms	Patupilone, Epothilone-B
SMILES	C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

Biological Activity

Epothilone B (EPO906)是一种紫杉醇样microtubule稳定剂。

Targets

Tubulin (Cell-free assay)
1.8 μM(EC0.01)

Solubility *

In vitro (25°C)	DMSO	93 mg/mL (183.18 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (183.18 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.7 mL	98.48 mL	196.97 mL
0.5 mM	3.94 mL	19.7 mL	39.39 mL
1 mM	1.97 mL	9.85 mL	19.7 mL
5 mM	0.39 mL	1.97 mL	3.94 mL

*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.