Erlotinib HCl
Catalog No. A10362
Erlotinib hydrochloride是一种可逆的酪氨酸激酶抑制剂,作用于表皮生长因子受体(EGFR)。
- Yuta Yamamoto, .et al. Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay, J Pharm Anal, 2018, Apr; 8(2): 119-123 PMID: 29736298
- Aikawa S, .et al. Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling, Biochem Biophys Res Commun, 2017, Feb 26;484(1):202-208 PMID: 28073697
Catalog Num | A10362 |
---|---|
M. Wt | 429.9 |
Formula | C22H23N3O4.HCl |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 183319-69-9 |
Synonyms | CP-358774, OSI-774, NSC 718781 |
SMILES | COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl |
Erlotinib hydrochloride是一种可逆的酪氨酸激酶抑制剂,作用于表皮生长因子受体(EGFR)。
Targets
HER1/EGFR (Cell-free assay) | ||||
2 nM |
In vitro (25°C) | DMSO | Warmed: 4 mg/mL (9.3 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 15% Captisol | 15 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.26 mL | 116.31 mL | 232.61 mL |
0.5 mM | 4.65 mL | 23.26 mL | 46.52 mL |
1 mM | 2.33 mL | 11.63 mL | 23.26 mL |
5 mM | 0.47 mL | 2.33 mL | 4.65 mL |
*The above data is based on the productmolecular weight 429.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.