Everolimus (RAD001)
Catalog No. A10374
Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物,与西罗莫司作为mTOR抑制剂的作用相似。
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Catalog Num | A10374 |
---|---|
M. Wt | 958.2 |
Formula | C53H83NO14 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 159351-69-6 |
Synonyms | SDZ-RAD, Certican, Zortress, Afinitor |
SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC |
Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物,与西罗莫司作为mTOR抑制剂的作用相似。
Targets
mTOR (FKBP12) (Cell-free assay) | ||||
1.6 nM-2.4 nM |
In vitro (25°C) | DMSO | 91 mg/mL (94.97 mM) | |
Water | Insoluble | ||
Ethanol | 6 mg/mL (6.26 mM) | ||
In vivo | 30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 10.44 mL | 52.18 mL | 104.36 mL |
0.5 mM | 2.09 mL | 10.44 mL | 20.87 mL |
1 mM | 1.04 mL | 5.22 mL | 10.44 mL |
5 mM | 0.21 mL | 1.04 mL | 2.09 mL |
*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.