Ezetimibe (Zetia)

Catalog No. A10379

Ezetimibe (Zetia)是一种有效的、选择性的胆固醇吸收抑制剂，用来降低胆固醇。

Product Citations

Nihei W, .et al. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains, J Lipid Res, 2018, Nov; 59(11): 2181-2187 PMID: 30242108

Technical details

Catalog Num	A10379
M. Wt	409.4
Formula	C24H21F2NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	163222-33-1
Synonyms	Zetia , Ezetrol
SMILES	C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O

Biological Activity

Ezetimibe (Zetia)是一种有效的、选择性的胆固醇吸收抑制剂，用来降低胆固醇。

Solubility *

In vitro (25°C)	DMSO	75 mg/mL (183.19 mM)
	Water	Insoluble
	Ethanol	75 mg/mL (183.19 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.43 mL	122.13 mL	244.26 mL
0.5 mM	4.89 mL	24.43 mL	48.85 mL
1 mM	2.44 mL	12.21 mL	24.43 mL
5 mM	0.49 mL	2.44 mL	4.89 mL

*The above data is based on the productmolecular weight 409.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.