Fisetin (Fustel)

Catalog No. A10388

Fisetin (Fustel)是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。

Product Citations

Bih-Cheng Chen, .et al. Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats, Phytomedicine, 2019, Apr; 57:1-8
Jeng LB, .et al. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo, J Cell Physiol, 2018, Sep;233(9):7134-7142 PMID: 29574877
Kuan-Ho Lin, .et al. Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats, Journal of Functional Foods, 2018, 52: 212-218

Technical details

Catalog Num	A10388
M. Wt	286.2
Formula	C15H10O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	528-48-3
Synonyms	Fustel, Viset
SMILES	C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

Biological Activity

Fisetin (Fustel)是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。

Targets

Sirtuin

Solubility *

In vitro	DMSO	56 mg/mL (195.64 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (10.48 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.94 mL	174.7 mL	349.41 mL
0.5 mM	6.99 mL	34.94 mL	69.88 mL
1 mM	3.49 mL	17.47 mL	34.94 mL
5 mM	0.7 mL	3.49 mL	6.99 mL

*The above data is based on the productmolecular weight 286.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.