Fludarabine (Fludara)

Catalog No. A10396

Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌,如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。
  • Irene Dell'Anno, .et al. Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma, Invest New Drugs, 2020, Dec 9 PMID: 33300108
Catalog Num A10396
M. Wt 285.2
Formula C10H12FN5O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 21679-14-1
Synonyms F-ara-A, NSC 118218
SMILES OC[C@@H]1O[C@@H]([C@@H]([C@H]1O)O)[C@@H]1C=Nc2c1nc(F)nc2N
Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌,如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。
Targets
STAT1 (Vascular smooth muscle cells)
In vitro (25°C) DMSO 52 mg/mL (182.3 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.06 mL 175.32 mL 350.63 mL
0.5 mM 7.01 mL 35.06 mL 70.13 mL
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL

*The above data is based on the productmolecular weight 285.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.