GDC-0941 (Pictilisib)

Catalog No. A10421

GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂，p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。

Product Citations

Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327

Technical details

Catalog Num	A10421
M. Wt	513.6
Formula	C23H27N7O3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	957054-30-7
Synonyms	GDC0941
SMILES	CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

Biological Activity

Targets

Target	Value
p110α	IC50: 3nM
p110δ	IC50: 3nM
p110β	IC50: 33nM
p110γ	IC50: 75nM
mTOR	Kiapp	0.58μM
C2β	IC50: 0.67μM
DNA-PK	IC50: 1.23μM
Vps34	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	40 mg/mL (77.87 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.35 mL	194.7 mL
0.5 mM	3.89 mL	19.47 mL	38.94 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.