Gefitinib (Iressa)

Catalog No. A10422

Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。

Product Citations

Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134

Technical details

Catalog Num	A10422
M. Wt	446.9
Formula	C22H24ClFN4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	184475-35-2
Synonyms	ZD-1839
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

Biological Activity

Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。

Targets

Tyr1173 (NR6W cells)	Tyr1173 (NR6wtEGFR cells)	Tyr992 (NR6wtEGFR cells)	Tyr992 (NR6W cells)
26 nM	37 nM	37 nM	57 nM

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (179 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (8.95 mM)
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.38 mL	111.88 mL	223.76 mL
0.5 mM	4.48 mL	22.38 mL	44.75 mL
1 mM	2.24 mL	11.19 mL	22.38 mL
5 mM	0.45 mL	2.24 mL	4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.