GSK1059615

Catalog No. A10438

GSK1059615是PI3Kα (IC50 = 2 nM)的强效、可逆、ATP竞争性噻唑烷二酮抑制剂。
  • Jing Xie, .et al. GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway, Oncotarget, 2017, Aug 1; 8(31): 50814-50823 PMID: 28881606
Catalog Num A10438
M. Wt 333.4
Formula C18H11N3O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 958852-01-2
Synonyms GSK-1059615
SMILES C1=CC2=NC=CC(=C2C=C1/C=C\3/C(=O)NC(=O)S3)C4=CC=NC=C4
GSK1059615是PI3Kα (IC50 = 2 nM)的强效、可逆、ATP竞争性噻唑烷二酮抑制剂。
Targets
PI3Kα PI3Kβ PI3Kδ PI3Kγ mTOR
0.4 nM0.6 nM2 nM5 nM12 nM
In vitro DMSO 2 mg/mL (5.99 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.99 mL 149.97 mL 299.94 mL
0.5 mM 6 mL 29.99 mL 59.99 mL
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL

*The above data is based on the productmolecular weight 333.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.