GSK461364

Catalog No. A10442

GSK461364 是polo样激酶1 (Plk1)的ATP竞争性抑制剂。

Technical details

Catalog Num	A10442
M. Wt	543.6
Formula	C27H28F3N5O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	929095-18-1
Synonyms	GSK 461364, GSK-461364
SMILES	C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

Biological Activity

GSK461364 是polo样激酶1 (Plk1)的ATP竞争性抑制剂。

Targets

PLK1 (Cell-free assay)
2.2 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	9 mg/mL (16.55 mM)
	Water	Insoluble
	Ethanol	27 mg/mL (49.66 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.4 mL	91.98 mL	183.96 mL
0.5 mM	3.68 mL	18.4 mL	36.79 mL
1 mM	1.84 mL	9.2 mL	18.4 mL
5 mM	0.37 mL	1.84 mL	3.68 mL

*The above data is based on the productmolecular weight 543.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.