Hesperadin

Catalog No. A10448

Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。

Product Citations

Wenbin Ji, .et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases, PLoS One, 2016, 11(4): e0153518 PMID: 27082996

Technical details

Catalog Num	A10448
M. Wt	516.7
Formula	C29H32N4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	422513-13-1
Synonyms
SMILES	CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5

Biological Activity

Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。

Targets

TbAUK1 (Cell-free assay)	Aurora B (human) (Cell-free assay)
40 nM	250 nM

Solubility *

In vitro (25°C)	DMSO	100 mg/mL (193.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40%PEG300+5% tween80+50% H2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.35 mL	96.77 mL	193.54 mL
0.5 mM	3.87 mL	19.35 mL	38.71 mL
1 mM	1.94 mL	9.68 mL	19.35 mL
5 mM	0.39 mL	1.94 mL	3.87 mL

*The above data is based on the productmolecular weight 516.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.