Ibuprofen (Advil)

Catalog No. A10461

Ibuprofen (Advil)是一种非甾体抗炎药(NSAID)，靶向COX-1，IC50为13 μM。

Product Citations

Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Technical details

Catalog Num	A10461
M. Wt	206.3
Formula	C13H18O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	15687-27-1
Synonyms	Genpril, Brufen, Nurofen, Motrin, Ibren, Ibuprohm
SMILES	CC(C)CC1=CC=C(C=C1)C(C)C(=O)O

Biological Activity

Ibuprofen (Advil)是一种非甾体抗炎药(NSAID)，靶向COX-1，IC50为13 μM。

Targets

COX-1	COX-2
13 μM	370 μM

Solubility *

In vitro (25°C)	DMSO	40 mg/mL (193.9 mM)
	Water	Insoluble
	Ethanol	40 mg/mL (193.9 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	48.47 mL	242.37 mL	484.73 mL
0.5 mM	9.69 mL	48.47 mL	96.95 mL
1 mM	4.85 mL	24.24 mL	48.47 mL
5 mM	0.97 mL	4.85 mL	9.69 mL

*The above data is based on the productmolecular weight 206.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.