IC-87114

Catalog No. A10463

IC-87114是首个同种型选择性PI3K抑制剂:p110M-NM-4(IC50 = 0.13 M-BM-5M)与p110M-NM-1(IC50 = 200 M-BM-5M)、p110M-NM-2(IC50 = 16 M-BM-5M)和p110M-NM-3(IC50 = 61 M-BM-5M)。
Catalog Num A10463
M. Wt 397.4
Formula C22H19N7O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 371242-69-2
Synonyms
SMILES CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C4N=CN=C5N
IC-87114是首个同种型选择性PI3K抑制剂:p110M-NM-4(IC50 = 0.13 M-BM-5M)与p110M-NM-1(IC50 = 200 M-BM-5M)、p110M-NM-2(IC50 = 16 M-BM-5M)和p110M-NM-3(IC50 = 61 M-BM-5M)。
Targets
PI3Kδ (Cell-free assay) PI3Kγ (Cell-free assay) PI3Kβ (Cell-free assay)
0.5 μM29 μM75 μM
In vitro (25°C) DMSO 0.62 mg/mL (1.56 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 0.6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.82 mL 251.64 mL
0.5 mM 5.03 mL 25.16 mL 50.33 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.