Imatinib Mesylate
Catalog No. A10468
Imatinib mesylate是一种选择性酪氨酸激酶抑制剂,通过抑制KIT信号转导途径,在治疗胃肠间质瘤中诱导了持续的客观反应。
- Inge Govaerts, .et al. PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia, J Hematol Oncol, 2021, 14: 97 PMID: 34167562
- Genevra Kuziel, .et al. Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells, Cancers (Basel), 2020, Jul 28;12(8):E2083 PMID: 32731354
Catalog Num | A10468 |
---|---|
M. Wt | 589.7 |
Formula | C29H31N7O.CH4SO3 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 220127-57-1 |
Synonyms | Gleevec, Glivec, CGP-57148B, STI-571 |
SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O |
Imatinib mesylate是一种选择性酪氨酸激酶抑制剂,通过抑制KIT信号转导途径,在治疗胃肠间质瘤中诱导了持续的客观反应。
Targets
PDGFR (Cell-free assay) | c-Kit (M-07e cells) | v-Abl (Cell-free assay) | ||
100 nM | 100 nM | 600 nM |
In vitro | DMSO | 101 mg/mL (171.26 mM) | |
Water | 101 mg/mL (171.26 mM) | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 16.96 mL | 84.79 mL | 169.58 mL |
0.5 mM | 3.39 mL | 16.96 mL | 33.92 mL |
1 mM | 1.7 mL | 8.48 mL | 16.96 mL |
5 mM | 0.34 mL | 1.7 mL | 3.39 mL |
*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.