Indirubin

Catalog No. A10471

Indirubin是中国抗白血病药物的活性成分,是一种有效的细胞周期蛋白依赖性激酶和GSK-3β抑制剂,IC50约为5 μM和0.6 μM。
Catalog Num A10471
M. Wt 262.3
Formula C16H10N2O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 479-41-4
Synonyms Couroupitine B, Indigo red
SMILES C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2
Indirubin是中国抗白血病药物的活性成分,是一种有效的细胞周期蛋白依赖性激酶和GSK-3β抑制剂,IC50约为5 μM和0.6 μM。
Targets
Target Value
GSK-3βIC50: 0.6μM
CDK2/CyclinAIC50: 2.2μM
CDK5/p35IC50: 5.5μM
CDK1/CyclinBIC50: 10μM
C-RafIC50: >10μM
CDK4/CyclinD1IC50: 12μM
c-SrcIC50: 18μM
ERK2IC50: 43μM
ERK1IC50: >100μM
MAPKKIC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: >100μM
PKCδIC50: >100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
PKCζIC50: >100μM
c-AblIC50: >1000μM
In vitro DMSO 48 mg/mL (183.02 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.12 mL 190.62 mL 381.24 mL
0.5 mM 7.62 mL 38.12 mL 76.25 mL
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL

*The above data is based on the productmolecular weight 262.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.