Irinotecan

Catalog No. A10478

Irinotecan通过抑制拓扑异构酶防止DNA解链。

Product Citations

Gils Jose, .et al. Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy, Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721
T Kannathasan, .et al. Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway, Cancers (Basel), 2020, May; 12(5): 1231 PMID: 32422901

Technical details

Catalog Num	A10478
M. Wt	586.7
Formula	C33H38N4O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	97682-44-5
Synonyms	Camptosar, CPT-11
SMILES	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Biological Activity

Irinotecan通过抑制拓扑异构酶防止DNA解链。

Targets

Topo I (LoVo, HT-29 cells)

Solubility *

In vitro (25°C)	DMSO	6 mg/mL (10.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.04 mL	85.22 mL	170.44 mL
0.5 mM	3.41 mL	17.04 mL	34.09 mL
1 mM	1.7 mL	8.52 mL	17.04 mL
5 mM	0.34 mL	1.7 mL	3.41 mL

*The above data is based on the productmolecular weight 586.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.