JNJ-7706621

Catalog No. A10494

JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂,IC50为9 nM/4 nM,并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B,对Plk1和Wee1没有活性。
  • Yuta Tanizaki, .et al. Thyroid hormone receptor α controls larval intestinal epithelial cell death by regulating the CDK1 pathway, Commun Biol, 2022, 5: 112 PMID: 35132135
Catalog Num A10494
M. Wt 394.4
Formula C15H12F2N6O3S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 443797-96-4
Synonyms JNJ7706621
SMILES C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂,IC50为9 nM/4 nM,并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B,对Plk1和Wee1没有活性。
In vitro (25°C) DMSO 67 mg/mL (169.89 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose+0.2% Tween 80 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.35 mL 126.77 mL 253.55 mL
0.5 mM 5.07 mL 25.35 mL 50.71 mL
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.