JNJ-7706621
Catalog No. A10494
JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂,IC50为9 nM/4 nM,并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B,对Plk1和Wee1没有活性。
- Yuta Tanizaki, .et al. Thyroid hormone receptor α controls larval intestinal epithelial cell death by regulating the CDK1 pathway, Commun Biol, 2022, 5: 112 PMID: 35132135
Catalog Num | A10494 |
---|---|
M. Wt | 394.4 |
Formula | C15H12F2N6O3S |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 443797-96-4 |
Synonyms | JNJ7706621 |
SMILES | C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F |
JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂,IC50为9 nM/4 nM,并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B,对Plk1和Wee1没有活性。
In vitro (25°C) | DMSO | 67 mg/mL (169.89 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 0.5% methylcellulose+0.2% Tween 80 | 13 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.35 mL | 126.77 mL | 253.55 mL |
0.5 mM | 5.07 mL | 25.35 mL | 50.71 mL |
1 mM | 2.54 mL | 12.68 mL | 25.35 mL |
5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.