Ketoconazole

Catalog No. A10498

ketoconazole作为抗真菌药在结构上类似于咪唑，并干扰真菌细胞膜组成成分麦角甾醇以及某些酶的真菌合成。

Technical details

Catalog Num	A10498
M. Wt	531.4
Formula	C26H28Cl2N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	65277-42-1
Synonyms	Nizoral, Extina, Xolegel, Kuric
SMILES	CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Biological Activity

ketoconazole作为抗真菌药在结构上类似于咪唑，并干扰真菌细胞膜组成成分麦角甾醇以及某些酶的真菌合成。

Targets

Cyclosporine oxidase	Testosterone 6 beta-hydroxylase
0.19 mM	0.22 mM

Solubility *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (9.4 mM)
	Water	Insoluble
	Ethanol	7 mg/mL
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.82 mL	94.09 mL	188.18 mL
0.5 mM	3.76 mL	18.82 mL	37.64 mL
1 mM	1.88 mL	9.41 mL	18.82 mL
5 mM	0.38 mL	1.88 mL	3.76 mL

*The above data is based on the productmolecular weight 531.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.