KRN 633

Catalog No. A10504

KRN 633是一种细胞可渗透、可逆、ATP竞争性VEGFR激酶抑制剂，仅在较高浓度下(IC50 = 0.97 μM和4.33 μM)抑制PDGFR-α和C-Kit，对其他17种激酶无活性(IC50 ≥ 10 μM)。

Technical details

Catalog Num	A10504
M. Wt	416.9
Formula	C20H21ClN4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	286370-15-8
Synonyms	KRN633, KRN-633
SMILES	CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl

Biological Activity

KRN 633是一种细胞可渗透、可逆、ATP竞争性VEGFR激酶抑制剂，仅在较高浓度下(IC50 = 0.97 μM和4.33 μM)抑制PDGFR-α和C-Kit，对其他17种激酶无活性(IC50 ≥ 10 μM)。

Targets

Target	Value
VEGFR3	IC50: 125nM
VEGFR2	IC50: 160nM
VEGFR1	IC50: 170nM
PDGFRα	IC50: 965nM
c-Kit	IC50: 4330nM
BTK	IC50: 9200nM
PDGFRβ	IC50: 9850nM
Tie-2	IC50: 9900nM

Solubility *

In vitro (25°C)	DMSO	8 mg/mL (19.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.99 mL	119.93 mL	239.87 mL
0.5 mM	4.8 mL	23.99 mL	47.97 mL
1 mM	2.4 mL	11.99 mL	23.99 mL
5 mM	0.48 mL	2.4 mL	4.8 mL

*The above data is based on the productmolecular weight 416.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.