KU-60019

Catalog No. A10507

KU-60019是一种强效特异性ATM抑制剂，IC50为6.3 nM。

Product Citations

Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
Hegedus C, .et al. PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis, Cancers (Basel), 2019, Dec 18;12(1) PMID: 31861350
Masaya Igase, .et al. Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma, Mol Ther Oncolytics, 2019, vol 15 PMID: 31650025
CHENGHUA LOU, .et al. Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells, Oncol Lett, 2016, Jul; 12(1): 295-300 PMID: 27347141

Technical details

Catalog Num	A10507
M. Wt	547.7
Formula	C30H33N3O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	925701-49-1, 925701-46-8
Synonyms	KU60019, KU-60019
SMILES	C[C@@H]1CN(C[C@@H](O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6

Biological Activity

KU-60019是一种强效特异性ATM抑制剂，IC50为6.3 nM。

Targets

ATM (Cell-free assay)
6.3 nM

Solubility *

In vitro	DMSO	Warmed: 18 mg/mL (32.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.26 mL	91.29 mL	182.58 mL
0.5 mM	3.65 mL	18.26 mL	36.52 mL
1 mM	1.83 mL	9.13 mL	18.26 mL
5 mM	0.37 mL	1.83 mL	3.65 mL

*The above data is based on the productmolecular weight 547.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.