Lopinavir (ABT-378)

Catalog No. A10537

Lopinavir (ABT-378)是HIV蛋白酶的抑制剂。

Technical details

Catalog Num	A10537
M. Wt	628.8
Formula	C37H48N4O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	192725-17-0
Synonyms	ABT-378
SMILES	CC1=C(C(=CC=C1)C)OCC(=O)N[C@@H](CC2=CC=CC=C2)[C@H](C[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)N4CCCNC4=O)O

Biological Activity

Lopinavir (ABT-378)是HIV蛋白酶的抑制剂。

Targets

HIV protease (Cell-free assay)
1.3 pM(Ki)

Solubility *

In vitro (25°C)	DMSO	116 mg/mL (184.48 mM)
	Water	Insoluble
	Ethanol	116 mg/mL (184.48 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.9 mL	79.52 mL	159.03 mL
0.5 mM	3.18 mL	15.9 mL	31.81 mL
1 mM	1.59 mL	7.95 mL	15.9 mL
5 mM	0.32 mL	1.59 mL	3.18 mL

*The above data is based on the productmolecular weight 628.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.