LY2784544 (Gandotinib)

Catalog No. A10546

LY2784544被鉴定为对JAK2-V617F具有高度选择性，并已进入人类临床试验，用于治疗几种骨髓增生性疾病。

Technical details

Catalog Num	A10546
M. Wt	469.9
Formula	C23H25ClFN7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1229236-86-5
Synonyms
SMILES	CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F

Biological Activity

LY2784544被鉴定为对JAK2-V617F具有高度选择性，并已进入人类临床试验，用于治疗几种骨髓增生性疾病。

Targets

Target	Value
JAK2(V617F)	ki: 0.245nM
JAK2	ki: 0.288nM
JAK2	IC50: 2.52nM
FLT3	IC50: 4nM
JAK1	IC50: 19.8nM
FLT4	IC50: 25nM
FGFR2	IC50: 32nM
TYK2	IC50: 44nM
JAK3	IC50: 48.0nM
TrkB	IC50: 95nM
FGFR3	IC50: 106nM
KDR	IC50: 109nM
ALK	IC50: 138nM
MUSK	IC50: 147nM
AuroraA	IC50: 168nM
MAP3K9	IC50: 299nM

Solubility *

In vitro	DMSO	92 mg/mL (195.76 mM)
	Water	Insoluble
	Ethanol	9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.28 mL	106.41 mL	212.81 mL
0.5 mM	4.26 mL	21.28 mL	42.56 mL
1 mM	2.13 mL	10.64 mL	21.28 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.