MC1568

Catalog No. A10560

MC1568是HDAC抑制剂的成员，它通过修饰细胞周期的各种重要基因的基因表达（主要在G1期）来抑制II类组蛋白脱乙酰基酶，从而导致细胞凋亡导致乳腺癌细胞死亡。

Product Citations

Vivek Bora, .et al. Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia, Can J Physiol Pharmacol, 2021, 6 October
Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760-1773 PMID: 29018096
S Ishikawa, .et al. Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer, Int J Cancer., 2014, 135(11): 2528-2536 PMID: 24346863
Usui T, .et al. Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells., Hypertension., 2014, Feb;63(2):397-403 PMID: 24166750

Technical details

Catalog Num	A10560
M. Wt	314.3
Formula	C17H15FN2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	852475-26-4
Synonyms	MC-1568
SMILES	CN1C=C(C=C1/C=C/C(=O)NO)/C=C/C(=O)C2=CC(=CC=C2)F

Biological Activity

Targets

HD1-A (Maize) (Cell-free assay)	HD1-B (Maize) (Cell-free assay)
100 nM	3.4 μM

Solubility *

In vitro (25°C)	DMSO	12 mg/mL (38.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.82 mL	159.08 mL	318.17 mL
0.5 mM	6.36 mL	31.82 mL	63.63 mL
1 mM	3.18 mL	15.91 mL	31.82 mL
5 mM	0.64 mL	3.18 mL	6.36 mL

*The above data is based on the productmolecular weight 314.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.