MGCD-265 (Glesatinib)

Catalog No. A10587

MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂，可与多种RTK（包括c-Met受体（HGFR）结合并抑制其磷酸化。Tek/Tie-2受体；VEGFR类型1、2和3；和MST1R。

Technical details

Catalog Num	A10587
M. Wt	517.6
Formula	C26H20FN5O2S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	875337-44-3
Synonyms	MGCD265
SMILES	CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F

Biological Activity

MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂，可与多种RTK（包括c-Met受体（HGFR）结合并抑制其磷酸化。Tek/Tie-2受体；VEGFR类型1、2和3；和MST1R。

Targets

Target	Value
Met	IC50: 1nM
RON	IC50: 2nM
VEGFR1	IC50: 3nM
VEGFR2	IC50: 3nM
VEGFR3	IC50: 4nM
Tie-2	IC50: 7nM

Solubility *

In vitro	DMSO	99 mg/mL (191.26 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.32 mL	96.6 mL	193.2 mL
0.5 mM	3.86 mL	19.32 mL	38.64 mL
1 mM	1.93 mL	9.66 mL	19.32 mL
5 mM	0.39 mL	1.93 mL	3.86 mL

*The above data is based on the productmolecular weight 517.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.