MLN2238 (Ixazomib)

Catalog No. A10600

MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点,IC50值为3.4 nM。
Catalog Num A10600
M. Wt 361.0
Formula C14H19BCl2N2O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1072833-77-2
Synonyms MLN 2238, MLN-2238
SMILES B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O
MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点,IC50值为3.4 nM。
Targets
20S proteasome (Cell-free assay) 20S proteasome (Cell-free assay)
0.93 nM(Ki)3.4 nM
In vitro (25°C) DMSO 64 mg/mL (177.26 mM)
Water Insoluble
Ethanol 8 mg/mL (22.15 mM)
In vivo 5% DMSO+45% PEG 300+ddH2O 16 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.7 mL 138.5 mL 277.01 mL
0.5 mM 5.54 mL 27.7 mL 55.4 mL
1 mM 2.77 mL 13.85 mL 27.7 mL
5 mM 0.55 mL 2.77 mL 5.54 mL

*The above data is based on the productmolecular weight 361.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.