MLN2238 (Ixazomib)
Catalog No. A10600
MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点,IC50值为3.4 nM。
Catalog Num | A10600 |
---|---|
M. Wt | 361.0 |
Formula | C14H19BCl2N2O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1072833-77-2 |
Synonyms | MLN 2238, MLN-2238 |
SMILES | B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O |
MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点,IC50值为3.4 nM。
Targets
20S proteasome (Cell-free assay) | 20S proteasome (Cell-free assay) | |||
0.93 nM(Ki) | 3.4 nM |
In vitro (25°C) | DMSO | 64 mg/mL (177.26 mM) | |
Water | Insoluble | ||
Ethanol | 8 mg/mL (22.15 mM) | ||
In vivo | 5% DMSO+45% PEG 300+ddH2O | 16 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 27.7 mL | 138.5 mL | 277.01 mL |
0.5 mM | 5.54 mL | 27.7 mL | 55.4 mL |
1 mM | 2.77 mL | 13.85 mL | 27.7 mL |
5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
*The above data is based on the productmolecular weight 361.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.