Motesanib Diphosphate (AMG-706)

Catalog No. A10608

Motesanib也称为AMG-706,是一种有效的ATP竞争性的VEGFR1/2/3抑制剂,IC50分别为2 nM/3 nM/6 nM;对Kit具有相似的抑制活性,对VEGFR选择性比PDGFR和Ret高10倍。
Catalog Num A10608
M. Wt 569.4
Formula C22H23N5O.2H3PO4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 857876-30-3
Synonyms AMG-706
SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O
Motesanib也称为AMG-706,是一种有效的ATP竞争性的VEGFR1/2/3抑制剂,IC50分别为2 nM/3 nM/6 nM;对Kit具有相似的抑制活性,对VEGFR选择性比PDGFR和Ret高10倍。
Targets
Target Value
VEGFR1IC50: 2nM
VEGFR2IC50: 3nM
VEGFR2/Flk1IC50: 6nM
VEGFR3IC50: 6nM
KitIC50: 8nM
RETIC50: 59nM
PDGFRIC50: 84nM
FGFRIC50: >2.8μM
EGFRIC50: >3μM
SrcIC50: >3μM
p38IC50: >3μM
In vitro (25°C) DMSO Warmed: 88 mg/mL (154.54 mM)
Water Warmed: 17 mg/mL (29.85 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.56 mL 87.81 mL 175.62 mL
0.5 mM 3.51 mL 17.56 mL 35.12 mL
1 mM 1.76 mL 8.78 mL 17.56 mL
5 mM 0.35 mL 1.76 mL 3.51 mL

*The above data is based on the productmolecular weight 569.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.