MP470 (MP-470, Amuvatinib)

Catalog No. A10610

MP470 (MP-470,Amuvatinib)是c-Kit/PDGFR酪氨酸激酶抑制剂。

Technical details

Catalog Num	A10610
M. Wt	447.5
Formula	C23H21N5O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	850879-09-3
Synonyms	Amuvatinib
SMILES	C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6

Biological Activity

MP470 (MP-470,Amuvatinib)是c-Kit/PDGFR酪氨酸激酶抑制剂。

Targets

c-Kit (D816H)	PDGFRα (V561D)	FLT3 (D835Y)
10 nM	40 nM	81 nM

Solubility *

In vitro (25°C)	DMSO	30 mg/mL (67.03 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+95% Corn oil	4.2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.35 mL	111.73 mL	223.46 mL
0.5 mM	4.47 mL	22.35 mL	44.69 mL
1 mM	2.23 mL	11.17 mL	22.35 mL
5 mM	0.45 mL	2.23 mL	4.47 mL

*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.