Naftopidil 2HCl

Catalog No. A10619

Naftopidil 2HCl是选择性5-HT1A和α1-肾上腺素能受体拮抗剂，IC50分别为0.1μM和0.2μM。

Technical details

Catalog Num	A10619
M. Wt	465.4
Formula	C24H28N2O3.2HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	57149-08-3
Synonyms	Flivas, KT-611, Avishot
SMILES	COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl

Biological Activity

Naftopidil 2HCl是选择性5-HT1A和α1-肾上腺素能受体拮抗剂，IC50分别为0.1μM和0.2μM。

Targets

5-HT1A	α1-adrenergic receptor
0.1 μM	0.2 μM

Solubility *

In vitro (25°C)	DMSO	35 mg/mL (75.2 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.29 mM)
In vivo	0.5% CMC	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.49 mL	107.43 mL	214.87 mL
0.5 mM	4.3 mL	21.49 mL	42.97 mL
1 mM	2.15 mL	10.74 mL	21.49 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

*The above data is based on the productmolecular weight 465.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.