NPI-2358 (Plinabulin)

Catalog No. A10654

NPI-2358 (Plinabulin)是NPI-2350的合成类似物，NPI-2350是从曲霉属（Aspergillus sp.）分离的天然产物，可解聚A549人肺癌细胞中的微管。

Technical details

Catalog Num	A10654
M. Wt	336.4
Formula	C19H20N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	714272-27-2
Synonyms	NPI2358
SMILES	CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2

Biological Activity

NPI-2358 (Plinabulin)是NPI-2350的合成类似物，NPI-2350是从曲霉属（Aspergillus sp.）分离的天然产物，可解聚A549人肺癌细胞中的微管。

Targets

Tubulin
9.8 nM-18 nM

Solubility *

In vitro	DMSO	Warmed: 49 mg/mL (145.66 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.73 mL	148.63 mL	297.27 mL
0.5 mM	5.95 mL	29.73 mL	59.45 mL
1 mM	2.97 mL	14.86 mL	29.73 mL
5 mM	0.59 mL	2.97 mL	5.95 mL

*The above data is based on the productmolecular weight 336.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.