NVP-BHG712

Catalog No. A10661

NVP-BHG712是EphB4激酶的选择性抑制剂，在体外对EphB4的选择性超过40多种其他激酶（包括FGFR3）。

Product Citations

Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924

Technical details

Catalog Num	A10661
M. Wt	503.5
Formula	C26H20F3N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	940310-85-0
Synonyms	NVPBHG712
SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

Biological Activity

NVP-BHG712是EphB4激酶的选择性抑制剂，在体外对EphB4的选择性超过40多种其他激酶（包括FGFR3）。

Targets

Target	Value
EphB4	ED50	25nM
C-Raf	IC50: 0.395μM
c-Src	IC50: 1.266μM
c-Abl	IC50: 1.667μM
Tie-2	IC50: >10μM
Axl	IC50: >10μM
HER1	IC50: >10μM
PKA	IC50: >10μM
CDK1	IC50: >10μM
PKB	IC50: >10μM
PDK-1	IC50: >10μM
FGFR3	IC50: >10μM
c-Met	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (178.75 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.95 mM)
In vivo	NMP+PEG300 (10+90, v+v)	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.86 mL	99.3 mL	198.61 mL
0.5 mM	3.97 mL	19.86 mL	39.72 mL
1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.4 mL	1.99 mL	3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.