ON-01910 (rigosertib)

Catalog No. A10673

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。

Technical details

Catalog Num	A10673
M. Wt	473.5
Formula	C21H24NNaO8S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1225497-78-8
Synonyms	ON01910, ON 01910.Na, Estybon, Novonex, Rigosertib
SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]

Biological Activity

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。

Targets

PLK1 (Cell-free assay)
9 nM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (179.52 mM)
	Water	85 mg/mL (179.52 mM)
	Ethanol	Insoluble
In vivo	water	90 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.12 mL	105.6 mL	211.19 mL
0.5 mM	4.22 mL	21.12 mL	42.24 mL
1 mM	2.11 mL	10.56 mL	21.12 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

*The above data is based on the productmolecular weight 473.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.