OSI-930

Catalog No. A10679

OSI-930是Kit，KDR，Flt，CSF-1R，c-Raf和Lck的有效抑制剂，IC50分别为80 nM，9 nM，8 nM，15 nM，41 nM和22 nM。

Technical details

Catalog Num	A10679
M. Wt	443.4
Formula	C22H16F3N3O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	728033-96-3
Synonyms	OSI930
SMILES	C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F

Biological Activity

OSI-930是Kit，KDR，Flt，CSF-1R，c-Raf和Lck的有效抑制剂，IC50分别为80 nM，9 nM，8 nM，15 nM，41 nM和22 nM。

Targets

Target	Value
FLT1	IC50: 8nM
KDR	IC50: 9nM
CSF-1R	IC50: 15nM
LCK	IC50: 22nM
C-Raf	IC50: 41nM
Kit	IC50: 80nM
FLT3	IC50: 1.303μM
PDGFRα	IC50: 3.408μM
Abl	IC50: 4.738μM
PDGFRβ	IC50: 6.9μM
EGFR	IC50: >10μM
AuroraA	IC50: >10μM
Axl	IC50: >10μM
CDK2/CyclinA	IC50: >10μM
IKKβ	IC50: >10μM
MEK1	IC50: >10μM
PDPK1	IC50: >10μM
PKBβ	IC50: >10μM
Tie-2	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (191.68 mM)
	Water	Insoluble
	Ethanol	3 mg/mL
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.76 mL	225.53 mL
0.5 mM	4.51 mL	22.55 mL	45.11 mL
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.