PD173074

Catalog No. A10703

PD173074是有效的，细胞可渗透的和ATP竞争性的FGFR和VEGFR抑制剂。

Product Citations

Cheryl Q.E. Lee, .et al. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast, Stem Cell Reports, 2016, Feb 9; 6(2): 257-272 PMID: 26862703

Technical details

Catalog Num	A10703
M. Wt	523.7
Formula	C28H41N7O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	219580-11-7
Synonyms	PD-173074
SMILES	CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C

Biological Activity

PD173074是有效的，细胞可渗透的和ATP竞争性的FGFR和VEGFR抑制剂。

Targets

Target	Value
FGFR1	IC50: ~25nM
VEGFR2	IC50: 100nM-200nM
c-Src	IC50: 19.8μM
EGFR	IC50: >50μM
Insulin Receptor	IC50: >50μM
MEK	IC50: >50μM
PKC	IC50: >50μM

Solubility *

In vitro (25°C)	DMSO	86 mg/mL (164.22 mM)
	Water	Insoluble
	Ethanol	86 mg/mL (164.22 mM)
In vivo	5% DMSO+corn oil	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.09 mL	95.47 mL	190.95 mL
0.5 mM	3.82 mL	19.09 mL	38.19 mL
1 mM	1.91 mL	9.55 mL	19.09 mL
5 mM	0.38 mL	1.91 mL	3.82 mL

*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.