PF-2341066 (Crizotinib)

Catalog No. A10712

PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖(IC50 = 30 nM)。
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Catalog Num A10712
M. Wt 450.3
Formula C21H22Cl2FN5O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 877399-52-5
Synonyms PF02341066
SMILES C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖(IC50 = 30 nM)。
Targets
c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells) ALK (Karpas299 cells)
11 nM24 nM
In vitro (25°C) DMSO 8 mg/mL (17.76 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+dd H2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.04 mL 222.07 mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.