PI-103

Catalog No. A10726

PI-103是一种有效的，细胞可渗透的，ATP竞争性磷脂酰肌醇3激酶（PI3K）家族抑制剂，对DNA-PK，PI3K（p110α）和mTOR具有选择性。

Product Citations

Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055

Technical details

Catalog Num	A10726
M. Wt	348.4
Formula	C19H16N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	371935-74-9
Synonyms	PI103
SMILES	C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O

Biological Activity

PI-103是一种有效的，细胞可渗透的，ATP竞争性磷脂酰肌醇3激酶（PI3K）家族抑制剂，对DNA-PK，PI3K（p110α）和mTOR具有选择性。

Targets

Target	Value
p110α	IC50: 2nM
p110β	IC50: 3nM
p110δ	IC50: 3nM
p110γ	IC50: 15nM
DNA-PK	IC50: 23nM
mTOR	IC50: 30nM

Solubility *

In vitro (25°C)	DMSO	22 mg/mL (63.15 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.7 mL	143.51 mL	287.03 mL
0.5 mM	5.74 mL	28.7 mL	57.41 mL
1 mM	2.87 mL	14.35 mL	28.7 mL
5 mM	0.57 mL	2.87 mL	5.74 mL

*The above data is based on the productmolecular weight 348.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.