PIK-294

Catalog No. A10728

PIK-294是PI3激酶抑制剂，其效力比母体化合物PIK-293高20至60倍。它是已报道的最有效的p110δ选择性抑制剂之一。

Technical details

Catalog Num	A10728
M. Wt	489.5
Formula	C28H23N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	900185-02-6
Synonyms	PIK294
SMILES	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=C(C(=N4)C6=CC(=CC=C6)O)C(=NC=N5)N

Biological Activity

PIK-294是PI3激酶抑制剂，其效力比母体化合物PIK-293高20至60倍。它是已报道的最有效的p110δ选择性抑制剂之一。

Targets

p110δ	p110γ	p110β
10 nM	160 nM	490 nM

Solubility *

In vitro	DMSO	91 mg/mL (185.89 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.43 mL	102.15 mL	204.29 mL
0.5 mM	4.09 mL	20.43 mL	40.86 mL
1 mM	2.04 mL	10.21 mL	20.43 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

*The above data is based on the productmolecular weight 489.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.