PIK-75 hydrochloride
Catalog No. A10729
PIK-75是一种p110α抑制剂,IC50值为5.8nM。在p110γ和p110β的效果较差,IC50值为0.076 ?M和1.3 ?M。
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Catalog Num | A10729 |
---|---|
M. Wt | 488.7 |
Formula | C16H14BrN5O4S.HCl |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 372196-77-5 |
Synonyms | PIK75 |
SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl |
PIK-75是一种p110α抑制剂,IC50值为5.8nM。在p110γ和p110β的效果较差,IC50值为0.076 ?M和1.3 ?M。
Targets
DNA-PK (Cell-free assay) | p110α (Cell-free assay) | p110γ (Cell-free assay) | p110δ (Cell-free assay) | p110β (Cell-free assay) |
2 nM | 5.8 nM | 76 nM | 0.51 μM | 1.3 μM |
In vitro | DMSO | Warmed: 4 mg/mL (8.18 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.46 mL | 102.31 mL | 204.62 mL |
0.5 mM | 4.09 mL | 20.46 mL | 40.92 mL |
1 mM | 2.05 mL | 10.23 mL | 20.46 mL |
5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.