PIK-75 hydrochloride

Catalog No. A10729

PIK-75是一种p110α抑制剂,IC50值为5.8nM。在p110γ和p110β的效果较差,IC50值为0.076 ?M和1.3 ?M。
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Catalog Num A10729
M. Wt 488.7
Formula C16H14BrN5O4S.HCl
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 372196-77-5
Synonyms PIK75
SMILES CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl
PIK-75是一种p110α抑制剂,IC50值为5.8nM。在p110γ和p110β的效果较差,IC50值为0.076 ?M和1.3 ?M。
Targets
DNA-PK (Cell-free assay) p110α (Cell-free assay) p110γ (Cell-free assay) p110δ (Cell-free assay) p110β (Cell-free assay)
2 nM5.8 nM76 nM0.51 μM1.3 μM
In vitro DMSO Warmed: 4 mg/mL (8.18 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.46 mL 102.31 mL 204.62 mL
0.5 mM 4.09 mL 20.46 mL 40.92 mL
1 mM 2.05 mL 10.23 mL 20.46 mL
5 mM 0.41 mL 2.05 mL 4.09 mL

*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.