PIK-90

Catalog No. A10730

PIK-90是一种合成的磷酸肌醇3激酶（PI3K）抑制剂，对于p110α，β，γ和δ亚型的IC50值（nM）为11、350、18和58，mTOR活性低。

Technical details

Catalog Num	A10730
M. Wt	351.4
Formula	C18H17N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	677338-12-4
Synonyms	PIK90
SMILES	COC1=C(C2=C(C=C1)C3=NCCN3C(=N2)NC(=O)C4=CN=CC=C4)OC

Biological Activity

PIK-90是一种合成的磷酸肌醇3激酶（PI3K）抑制剂，对于p110α，β，γ和δ亚型的IC50值（nM）为11、350、18和58，mTOR活性低。

Targets

PI3Kα	PI3Kγ	PI3Kδ	PI3Kβ
11 nM	18 nM	58 nM	350 nM

Solubility *

In vitro (25°C)	DMSO	0.27 mg/mL (0.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.46 mL	142.29 mL	284.58 mL
0.5 mM	5.69 mL	28.46 mL	56.92 mL
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL

*The above data is based on the productmolecular weight 351.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.