PIK-93

Catalog No. A10731

PIK-93是第一个有效的，人工合成的PI4K(PI4KIIIβ)抑制剂，IC50为19 nM；抑制PI3Kα，IC50为39 nM。

Product Citations

Gavin Ka Yu Siu, .et al. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation, Sci Rep, 2016, 6: 23464 PMID: 27010100

Technical details

Catalog Num	A10731
M. Wt	389.9
Formula	C14H16ClN3O4S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	593960-11-3
Synonyms	PIK93
SMILES	CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO

Biological Activity

PIK-93是第一个有效的，人工合成的PI4K(PI4KIIIβ)抑制剂，IC50为19 nM；抑制PI3Kα，IC50为39 nM。

Targets

Target	Value
p110γ	IC50: 16nM
PI4KIIIβ	IC50: 19nM
p110α	IC50: 39nM
DNA-PK	IC50: 64nM
p110δ	IC50: 120nM
C2β	IC50: 140nM
hsVps34	IC50: 320nM
ATM	IC50: 490nM
p110β	IC50: 590nM
PI4KIIIα	IC50: 1.1μM
mTORC1	IC50: 1.38μM
C2α	IC50: 16μM
ATR	IC50: 17μM
PI4KIIα	IC50: >100μM
PI4P5KIα	IC50: >100μM
PI4P5KIβ	IC50: >100μM
PI5P4KIIβ	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	69 mg/mL (176.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.65 mL	128.24 mL	256.48 mL
0.5 mM	5.13 mL	25.65 mL	51.3 mL
1 mM	2.56 mL	12.82 mL	25.65 mL
5 mM	0.51 mL	2.56 mL	5.13 mL

*The above data is based on the productmolecular weight 389.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.