Pitavastatin calcium (Livalo)

Catalog No. A10737

Pitavastatin calcium (Livalo)是HMGCR（HMG-CoA还原酶）酶的竞争性抑制剂，可降低LDL胆固醇的合成。

Product Citations

Weizhen Chen, .et al. An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties, Biomaterials, 2021, 280:121260 PMID: 34823885
Karis Tutuska, .et al. Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins, Cell Death Dis, 2020, Apr; 11(4): 274 PMID: 32332697
D Jarmuzek, .et al. Phototransformations of pitavastatin - The inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, J Photochem Photobiol A Chem, 2019, November
Marwan Ibrahim Abdullah, .et al. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells, Sci Rep, 2017, 7: 8090 PMID: 28808351

Technical details

Catalog Num	A10737
M. Wt	880.98
Formula	(C25H23FNO4)2.Ca
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	147526-32-7
Synonyms	Livalo
SMILES	C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]

Biological Activity

Pitavastatin calcium (Livalo)是HMGCR（HMG-CoA还原酶）酶的竞争性抑制剂，可降低LDL胆固醇的合成。

Targets

cholesterol esters

Solubility *

In vitro	DMSO	46 mg/mL (52.21 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.35 mL	56.75 mL	113.51 mL
0.5 mM	2.27 mL	11.35 mL	22.7 mL
1 mM	1.14 mL	5.68 mL	11.35 mL
5 mM	0.23 mL	1.14 mL	2.27 mL

*The above data is based on the productmolecular weight 880.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.