R935788 (Fostamatinib disodium, R788)

Catalog No. A10771

R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂，可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。

Technical details

Catalog Num	A10771
M. Wt	624.4
Formula	C23H24FN6O9P.2Na
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1025687-58-4
Synonyms	R-935788, Fostamatinib disodium, R788
SMILES	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]

Biological Activity

R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂，可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。

Targets

Syk (Cell-free assay)
41 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (8 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80,pH6.5	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.02 mL	80.08 mL	160.15 mL
0.5 mM	3.2 mL	16.02 mL	32.03 mL
1 mM	1.6 mL	8.01 mL	16.02 mL
5 mM	0.32 mL	1.6 mL	3.2 mL

*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.