Raltegravir (MK-0518)

Catalog No. A10775

Raltegravir (MK-0518)靶向整合酶，这是一种HIV酶，可将病毒遗传物质整合到人类染色体中，这是HIV发病机理中的关键步骤。

Product Citations

Michal S Barski, .et al. Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures, Nat Commun, 2021, Aug 17;12(1):4996 PMID: 34404793
Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1

Technical details

Catalog Num	A10775
M. Wt	444.4
Formula	C20H21FN6O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	518048-05-0
Synonyms	Isentress, MK0518, MK-0518
SMILES	CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)[O-])C(=O)NCC3=CC=C(C=C3)F.[K+]

Biological Activity

Raltegravir (MK-0518)靶向整合酶，这是一种HIV酶，可将病毒遗传物质整合到人类染色体中，这是HIV发病机理中的关键步骤。

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (180.01 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.5 mL	112.51 mL	225.02 mL
0.5 mM	4.5 mL	22.5 mL	45 mL
1 mM	2.25 mL	11.25 mL	22.5 mL
5 mM	0.45 mL	2.25 mL	4.5 mL

*The above data is based on the productmolecular weight 444.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.