Ramelteon (TAK-375)

Catalog No. A10777

Ramelteon (TAK-375)是melatonin受体激动剂，对褪黑激素MT1（IC50 = 28.5±8.55 pM）和MT2（20.1±9.25 pM）受体均具有高亲和力，并且相对于MT3受体具有选择性。

Technical details

Catalog Num	A10777
M. Wt	259.3
Formula	C16H21NO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	196597-26-9
Synonyms	Rozerem, TAK-375, TAK375
SMILES	CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3

Biological Activity

Ramelteon (TAK-375)是melatonin受体激动剂，对褪黑激素MT1（IC50 = 28.5±8.55 pM）和MT2（20.1±9.25 pM）受体均具有高亲和力，并且相对于MT3受体具有选择性。

Targets

MT1 receptor	MT receptor (chicken)	MT2 receptor
14 pM(Ki)	23.1 pM(Ki)	112 pM(Ki)

Solubility *

In vitro (25°C)	DMSO	47 mg/mL (181.22 mM)
	Water	Insoluble
	Ethanol	47 mg/mL (181.22 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.57 mL	192.83 mL	385.65 mL
0.5 mM	7.71 mL	38.57 mL	77.13 mL
1 mM	3.86 mL	19.28 mL	38.57 mL
5 mM	0.77 mL	3.86 mL	7.71 mL

*The above data is based on the productmolecular weight 259.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.