Rifabutin

Catalog No. A10790

Rifabutin是一种主要用于治疗肺结核的杀菌抗生素。它的作用是基于阻断细菌的DNA依赖性RNA聚合酶。

Product Citations

Matt D Johansen, .et al. Rifabutin is bactericidal against intracellular and extracellular forms of Mycobacterium abscessus, Antimicrob Agents Chemother, 2020, Aug 17;AAC.00363-20 PMID: 32816730
Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
Dinah Binte Aziz, .et al. Rifabutin Is Active against Mycobacterium abscessus Complex, Antimicrob Agents Chemother, 2017, Jun; 61(6): e00155-17 PMID: 28396540

Technical details

Catalog Num	A10790
M. Wt	847.0
Formula	C46H62N4O11
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	72559-06-9
Synonyms	Mycobutin
SMILES	C[C@H]1/C=C/C=C(\C(=O)NC2=C3C(=NC4(N3)CCN(CC4)CC(C)C)C5=C6C(=C(C(=C5C2=O)O)C)O[C@@](C6=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)/C

Biological Activity

Rifabutin是一种主要用于治疗肺结核的杀菌抗生素。它的作用是基于阻断细菌的DNA依赖性RNA聚合酶。

Solubility *

In vitro	DMSO	59 mg/mL (69.65 mM)
	Water	Insoluble
	Ethanol	39 mg/mL (46.04 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.81 mL	59.03 mL	118.06 mL
0.5 mM	2.36 mL	11.81 mL	23.61 mL
1 mM	1.18 mL	5.9 mL	11.81 mL
5 mM	0.24 mL	1.18 mL	2.36 mL

*The above data is based on the productmolecular weight 847.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.