Risperidone (Risperdal)

Catalog No. A10797

Risperidone (Risperdal)是一种非典型的抗精神病药，用于治疗精神分裂症（包括青少年精神分裂症），精神分裂症，躁郁症的躁狂和躁狂状态，以及自闭症儿童的烦躁不安。

Product Citations

Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
Jaime Osuna-Luque, .et al. Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole, J Exp Neurosci, 2018, 12: 1179069518798628 PMID: 30245571

Technical details

Catalog Num	A10797
M. Wt	410.5
Formula	C23H27FN4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	106266-06-2
Synonyms	R 64 766, Risperdal
SMILES	CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

Biological Activity

Targets

Target	Value
5-HT2A	ki: 0.17nM
α2c-adrenergicreceptor	ki: 1.3nM
D2receptor	ki: 3.57nM
D3receptor	ki: 3.6nM
D2LReceptor	ki: 4.16nM
D4receptor	ki: 4.66nM
D2SReceptor	ki: 4.73nM
α1A-adrenergicreceptor	ki: 5nM
5-HT7	ki: 6.6nM
α1B-adrenergicreceptor	ki: 9nM
5-HT2C	ki: 12nM
5-HT1B	ki: 14.9nM
α2a-adrenergicreceptor	ki: 16.5nM
H1receptor	ki: 20.1nM
5-HT2B	ki: 61.9nM
5-HT1D	ki: 84.6nM
α2b-adrenergicreceptor	ki: 108nM
H2receptor	ki: 120nM
5-HT5A	ki: 206nM
5-HT5A	ki: 206nM
D1receptor	ki: 244nM
D5receptor	ki: 290nM
5-HT1A	ki: 423nM
5-HT6	ki: 2060nM

Solubility *

In vitro	DMSO	Warmed: 4 mg/mL (9.74 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (9.74 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.36 mL	121.8 mL	243.61 mL
0.5 mM	4.87 mL	24.36 mL	48.72 mL
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL

*The above data is based on the productmolecular weight 410.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.