Ritonavir

Catalog No. A10799

Ritonavir是一种蛋白酶抑制剂，具有抗人类免疫缺陷病毒1型(hiv-1)的活性。蛋白酶抑制剂阻断hiv中被称为蛋白酶的部分，利托那韦抑制hiv病毒蛋白酶，这种蛋白酶防止gag-pol多蛋白的裂解，从而产生非感染性的未成熟病毒颗粒。

Technical details

Catalog Num	A10799
M. Wt	720.9
Formula	C37H48N6O5S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	155213-67-5
Synonyms	Norvir, Norvir Softgel
SMILES	CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O

Biological Activity

Targets

CYP3A4	HIV

Solubility *

In vitro (25°C)	DMSO	94 mg/mL (130.38 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (4.16 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.87 mL	69.36 mL	138.72 mL
0.5 mM	2.77 mL	13.87 mL	27.74 mL
1 mM	1.39 mL	6.94 mL	13.87 mL
5 mM	0.28 mL	1.39 mL	2.77 mL

*The above data is based on the productmolecular weight 720.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.