SB 202190

Catalog No. A10823

SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。

Product Citations

Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215

Technical details

Catalog Num	A10823
M. Wt	331.3
Formula	C20H14N3OF
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	152121-30-7
Synonyms	SB-202190, SB202190
SMILES	C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

Biological Activity

SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。

Targets

p38α (Cell-free assay)	p38β (Cell-free assay)
50 nM	100 nM

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (187.12 mM)
	Water	Insoluble
	Ethanol	11 mg/mL (33.19 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%H2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.18 mL	150.92 mL	301.84 mL
0.5 mM	6.04 mL	30.18 mL	60.37 mL
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.6 mL	3.02 mL	6.04 mL

*The above data is based on the productmolecular weight 331.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.