SB 525334

Catalog No. A10827

SB525334是转化生长因子-β受体I（ALK5，TGF-βRI）的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。

Technical details

Catalog Num	A10827
M. Wt	343.4
Formula	C21H21N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	356559-20-1
Synonyms	SB-525334, SB525334
SMILES	CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3

Biological Activity

SB525334是转化生长因子-β受体I（ALK5，TGF-βRI）的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。

Targets

TGFβR1(ALK5) (Cell-free assay)
14.3 nM

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (195.09 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (195.09 mM)
In vivo	5% DMSO+corn oil	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.12 mL	145.6 mL	291.21 mL
0.5 mM	5.82 mL	29.12 mL	58.24 mL
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL

*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.