SB 743921

Catalog No. A10828

SB 743921是第二代KSP抑制剂,在癌症的临床前模型中是一种高效有效的治疗剂。
Catalog Num A10828
M. Wt 553.5
Formula C31H33N2O3.HCl
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 940929-33-9
Synonyms SB-743921, SB743921
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
SB 743921是第二代KSP抑制剂,在癌症的临床前模型中是一种高效有效的治疗剂。
Targets
Target Value
KSP(MX1cells)IC50: 0.06nM
KSP(Colo205cells)IC50: 0.07nM
KSPki: 0.1nM
KSP(SKOV3cells)IC50: 0.2nM
KSP(MV522cells)IC50: 1.7nM
KSP(P388cells)IC50: 14.4nM
In vitro (25°C) DMSO 103 mg/mL (186.08 mM)
Water 20 mg/mL (36.13 mM)
Ethanol 103 mg/mL (186.08 mM)
In vivo Saline pH5.0 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.07 mL 90.33 mL 180.67 mL
0.5 mM 3.61 mL 18.07 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.