SB590885

Catalog No. A10829

SB590885是B-Raf激酶的选择性小分子抑制剂，B-Raf和c-Raf的Ki app值分别为0.16和1.72 nM。

Technical details

Catalog Num	A10829
M. Wt	453.5
Formula	C27H27N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	405554-55-4
Synonyms	SB-590885
SMILES	CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2

Biological Activity

SB590885是B-Raf激酶的选择性小分子抑制剂，B-Raf和c-Raf的Ki app值分别为0.16和1.72 nM。

Targets

B-Raf (Cell-free assay)
0.16 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (11.02 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.05 mL	110.25 mL	220.51 mL
0.5 mM	4.41 mL	22.05 mL	44.1 mL
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL

*The above data is based on the productmolecular weight 453.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.